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[5] Many substances in cigarette smoke, chiefly nicotine, trigger chemical reactions in nerve endings, which heighten heart rate, alertness [6] and reaction time, among other things

New Zealand also has policies to reduce the nicotine content in cigarettes to non-addictive levels and prohibits selling cigarettes to individuals born after 2008

Rates of cellular glucose consumption and lactate production were significantly reduced under both effects, but the reduction was more pronounced with nutrient deprivation (indirect effect) than with CSE treatment (direct effect)