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[98] There are also a number of drugs where the anti-folate effect is unintended

Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat

(2015) 33:203.e19203.e25

Pioglitazone, a diabetes medication, may benefit selected patients with biopsy-proven NASH, but is also specialist-led and off-label , with potential risks including weight gain, fluid retention, heart failure, and increased fracture risk

Typical oral doses range from 5001500 mg daily in divided doses to account for this limitation

Data acquisition and processing for flow cytometry were conducted using CytExpert software