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As of 1998, the FDA has required that all food manufacturers fortify enriched grain products with folic acid to reduce the risk of congenital neural tube defects

All animal experiments were conducted in accordance with ARRIVE guidelines to ensure ethical and transparent reporting of in vivo research 28

However, T-cell dysfunction may speed up aging

in Italy assessed the efficacy of a hydrolyzed collagen supplement (5 g per day) to improve skin moisturization, elasticity, and the appearance of wrinkles in 52 women (4060 years of age), where 26 women received the supplement and 26 women were given a placebo for a total of 56 days [41]