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SOD3 is an extracellular SOD that is present at high levels in epididymis fluid and at low levels in spermatogenic cells (94)

Nutr Metab 14:78 Forges T, Monnier-Barbarino P, Alberto JM, Guant-Rodriguez RM, Daval JL, Guant JL (2007) Impact of folate and homocysteine metabolism on human reproductive health

it is stable across a wide pH range (~4-8), works well with other ingredients, and is considered non-sensitizing/non-irritating

Niacinamide - 4% A powerful antioxidant that improves skin texture, reduces inflammation, and minimizes the appearance of pores while balancing oil production

doi:10.1016/S0021-9258(18)46868-8