Even though the specific roles that NKCC2 in these organs may have in glucose homeostasis remain unexplored, the potential relevance of extrarenal NKCC2 is underlined by the following: i ) the gluconeogenic capacity (Watford, 2005) of the small intestine supplies circulating glucose (Penhoat et al., 2014) and prevents obesity-related hepatic steatosis (Vily-Petit et al., 2020), ii ) the hypothalamus plays a central role in endocrine integration of fuel homeostasis, control of water/energy intake and feeding behavior (Schwartz et al., 2000
Six-to-eight-week-old female DBA/2 mice were purchased from the Jackson Laboratory (Indianapolis, IN) and housed in the LSUHSC-S Animal Resource Facility (four in one cage in microisolators) under standard regulations
By creating a high-IGF-1 environment, researchers can study the effects on body composition, specifically the potential for promoting lean mass accretion while simultaneously aiding fat metabolism
[DOI] [PubMed] [Google Scholar] 112.Van Kruijsdijk R.C.M., Van Der Wall E., Visseren F.L.J
Gastrointestinal Studies By encouraging healing and reducing damage, BPC-157 has demonstrated potential in safeguarding the gastrointestinal system
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