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The reflux of stomach contents can irritate the airways and lungs, and further worsen respiratory symptoms such as coughing and shortness of breath and diminishing the quality of life for COPD patients [80]

Gao Y-T, Zheng W, Zhang Y, Gao RN, Xu CW, Liao ML, Yang ZP, Lin ZQ, Wang ZX, Zhao JJ, et al: A casecontrol study of lung cancer among women in Shanghai