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This nuclear presence of FOXO4 seems to be involved in maintaining the viability of senescent cells by possibly modulating downstream senescence-associated pathways, detailed by changes in p53, Ser15-phospho-p53, and p21 protein levels

doi: 10.1016/j.pnpbp.2020.110111 15 KlengelTBinderEB

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While cancer remains uncommon compared to other causes, doctors may order additional testing to rule out gastrointestinal cancers or blood cancers when symptoms continue worsening

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