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Treatment of Drosophila flies with kynurenine pathway inhibitors and the NAD + precursors NR or NAM increased the lifespan of these animals, suggesting an advantage in combining different therapeutic strategies

Glutathione is often referred to as the body's "master antioxidant" due to its crucial role in neutralizing free radicals, strengthening the immune system, supporting detoxification processes, and enhancing the function of other antioxidants like vitamins C and E

SFN treatment also reduced the activation of STAT3 and NF-B pathways and downregulated pro-inflammatory cytokines IL-1, IL-6, and CCL2

Proteins were separated on 4-12% Bis-Tris gels (Life Technologies, MW04125) and transferred to PVDF membranes

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