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In some embodiments, an otic composition or formulation disclosed herein comprises less than about 25 ppm of each of C1-C4 alcohols or C1-C4 glycols

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The timeline varies based on starting dose, escalation speed, and individual factors like dietary habits and hydration status

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Complex I (NADH: ubiquinone oxidoreductase) is the primary entry point of electrons into the respiratory chain, passing reducing equivalents from NADH to CoQ 46