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[34] induced the apoptosis of rat pulmonary vascular endothelial cells by intraperitoneal injection of cigarette smoke extract (CSE) in 2005 and successfully established a rat emphysema model

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Studies using a variety of different puffing regimes showed no increase in the formation of toxicants, and clinical studies in which participants could use the product freely demonstrated reductions in exposure to toxicants approaching 95% of the reductions seen in smokers who quit for the duration of the study

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