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The response to EX + SFN was significantly greater than either SFN or EX alone (2.1-fold versus 1.5-fold, p = 0.01)

Solute carrier family 7 member 11 (SLC7A11) is the main active subunit of system Xc-, and it regulates the dynamic GSH level to maintain its equilibrium and thus regulate ferroptosis [7, 68]

The standard protocol involves 5 to 10 mg daily via subcutaneous injection for 10 to 20 consecutive days, repeated once or twice per year with 4 to 6 months between cycles

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Later [10], Griffith reported the use of 2VP, instead of NEM, which does not inhibit GR, and, therefore, need not be removed from the sample

It leads to infectious mononucleosis and may play a role in the development of Burkitt lymphoma, some nasopharyngeal carcinomas, and a few rare genetic lymphoproliferative disorders