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doi: 10.3389/fphar.2017.00904 Received 03 October 2017 Accepted 28 November 2017 Published 12 December 2017 Volume 8 - 2017 Edited by Alfonso Pompella, University of Pisa, Italy Reviewed by Claudio Sorio, University of Verona, Italy

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Immunoblot To measure Akt phosphorylation, confluent bFLS were treated with bTNF- for 5 min at 37 C under 5% CO 2

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Bioactive phenolic compounds may interact with disulfide bridges on the enzyme surface, altering its structure and reducing ACE activity (391)