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We understand these diseases cannot be fully grasped without the correct assumption of the molecular and cellular interactions present in their pathogenesis

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Cytoplasmic IDH1 and mitochondrial isocitrate dehydrogenase 2 (IDH2) reversibly synthesize -ketoglutarate from isocitrate and function in the reversible mitochondrial citrate--ketoglutarate shuttle (CAS) that shuttles NADPH reducing equivalents between the cytoplasm and the mitochondrial matrix (Figure 2D)

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The two compounds belong to mechanistically complementary categories used in laboratory studies of pulsatile growth hormone signalling