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More specifically, epidermal sphingolipids have been shown to be altered only in aged female skin [90], an effect that can be reversed by HRT [91, 92]

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In 1992, two additional neutrophil-derived antimicrobial peptides were found, equine neutrophil antimicrobial peptide 1 (eNAP-1) and eNAP-2 [32, 33]

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1 When IGF-1 binds to IGF-1R, the tyrosine kinase activates the phosphoinositide 3-kinase (PI3K)-AKT pathway and many integral proteins involved in cellular metabolism, apoptosis, cell adhesion, and angiogenesis are regulated within this pathway