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The human tyrosinase structure, predicted using AlphaFold3, estimated a high confidence value (pLDDT mostly above 90)

The principal mechanism driving AOPPs generation involves the activated myeloperoxidase-H 2 O 2 -chloride system in neutrophils, with myeloperoxidase serving as the sole enzyme capable of generating chlorinated oxidants (Figure 2) ( FIGURE 2 As markers of oxygen-mediated protein damage, AOPPs have been identified as indicators of oxidative protein damage and proinflammatory mediators ( 3.2.2 Advanced glycation end- products Advanced glycation end-products (AGEs) and AOPPs share structural similarities and exert comparable biological effects

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10.1016/j.intimp.2020.107132 205 Wang FangW

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