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Through the integrated function of these domains, STAT5 serves as a critical node in cytokine-induced intracellular signal transduction and nuclear transcriptional regulation ( Collectively, activation of the long-form prolactin receptor (PRLR) initiates the canonical JAK2/STAT5 signaling cascade, which is the principal pathway underlying the diverse biological actions of PRLR (24)

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Long-term IV administration (12 months) of l-carnitine (2 g/day) to patients undergoing hemodialysis resulted in increased serum and muscle carnitine levels, together with hypertrophy and predominance of type I fibers [43] in the muscle