RSL3 Pack Size:10 mM * 1 mL in DMSO inhibits estrogen receptor α expression

inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK

for p38γ=200 nM

Cetuximab has potent antitumor activity

trichloroacetic acid (TCA) precipitation emerges as a straightforward and efficient method

MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein

RSL3 Pack Size:10 mM * 1 mL in DMSO inhibits estrogen receptor α expressionRSL3 ((1S,3R) RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3 rslR cells.