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doi: 10.1056/NEJMra1510030 3 BartalenaLBaldeschiLBoboridisKEcksteinAKahalyGJMarcocciCet al
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Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress
The overexpression of CPT1A is often associated with tumor progression in several cancers such as breast, gastric, prostate, lymphoma, leukemia, ovarian, lung, and myeloma 20,21,22,23