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Analysis of the PPARGC1A promoter sequence up to 2,000 bp before the transcription initiation site (Genomatix) and sequence comparison between the human and murine PPARGC1A promoter sequence (CLUSTAL O 1.2.0 sequence alignment software) (Supplemental Figure 4A) identified 5 conserved PPREs that span regions 1631/1609 bp, 1386/1362 bp, 1012/991 bp, 634/612 bp, and 210/189 bp (Supplemental Figure 4B)

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