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available at Ethics statement The animal study was approved by the Ethics Committee of Shandong Rongjun General Hospital (No: RY00006)

High NNMT exacerbates cell oxidative stress and apoptosis, worsening disease progression

ERK1/2 Activation Extracellular signal-regulated kinases 1 and 2 trigger transcription factors c-Fos and c-Jun when activated by BPC-157

doi: 10.1016/j.bbrc.2004.08.145 72 WangJPolakiVChenSBihlJC

Nrf2, a nuclear transcription factor, translocates to the cell nucleus to upregulate HO-1, converting heme to biliverdin, iron, and CO [108]

Edema impairs healing by increasing tissue pressure, reducing blood flow, and creating barriers to cell migration