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Hematocrit and reticulocyte counts should be repeated daily from the fifth to seventh days of therapy, and then frequently until the hematocrit is normal

Researchers and clinicians using it do so based on extrapolation from animal data and accumulating clinical experience rather than proven efficacy in humans

[1] Natural NAD+ levels decline progressively with age

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This makes the compound a cleaner tool for isolating fat-metabolism effects in experimental research where mitogenic side effects would confound results