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The 80% increase in dentate gyrus neurogenesis and the reversal of dendritic and synaptic density loss make P21 particularly suited to the recovery phase, where the goal is not preventing further damage but restoring function

The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage

The assay involves carefully optimized enzymatic recycling method using glutathione reductase and Ellmans reagent (DTNB) 2

Along with oxidative stress, these abnormal molecular changes lead to impaired mitochondrial respiratory function, ATP depletion, and various destructive cellular processes, such as mitochondrial fission, mitophagy, and programmed cell death, as we discuss below

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MS, metabolic syndrome