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Given the safety of vitamin B12, it would be more favorable to treat FM patients with a longer duration to achieve a larger effect on pain and psychological illness improvement

This is especially beneficial for individuals with gastrointestinal absorption issues, where oral supplements fail to deliver results

Typically autoclaving at 121C for 15 minutes

Aim for at least 50 mg of vitamin C to significantly increase iron absorption at a meal

However, a small randomized, double-blind, placebo-controlled trial in 450 pregnant women at high risk for preeclampsia found that supplementation with 15 mg of riboflavin daily did not prevent the condition (61)