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Management of MetS risk factors The metabolic risk variables in the syndromes definition include atherogenic dyslipidemia, elevated blood pressure, high plasma glucose, a prothrombotic condition, and a pro-inflammatory state ( Reduction in blood pressure has been demonstrated to reduce the risk of severe CVD in several clinical studies, including those involving people with type-2 diabetes ( A prothrombotic state is indicated by elevated levels of fibrinogen, plasminogen activator inhibitor-1, and other coagulation components