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Correcting a deficiency can remove one biological contributor to low mood, and some people notice less irritability and a more positive outlook

Our moderate sample size may have limited our ability to detect clinical differences in the study arms, and we were not powered to detect differences in birth outcomes, including the frequency of LBW and IUGR

Folic acid (vitamin B9) works synergistically with B12, helping in the production of red blood cells and supporting healthy nerve function

These results have not been replicated in human clinical trials, so it is unclear whether these effects translate to human patients

Sources: Dimet-Wiley AL, Latham CM, Brightwell CR, et al

When B12 levels are low, fatigue, weakness, poor focus, and low mood can become more noticeable