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The reduction in endothelial NO in cardiovascular disease has been attributed to the action of oxidants that either directly react with NO or uncouple its substrate enzyme

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2 It has also been shown that nuclear receptor coactivator 4 (NCOA4) releases a large amount of labile iron to induce ferroptosis through lysosomal degradation of ferritin heavy chain 1 (FTH1)

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Consortia must also include at least one funded patient partner, brought in through a PAO or another organised patient group, and must secure access to a qualified multinational Clinical Trial Management Organisation (CTMO)

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