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Transferrin receptor 1 (TfR1), a well-known regulator of cellular iron that internalizes the transferrin-bound iron, plays a significant role in ferroptosis, and ROS induction has been shown to enhance TfR1 protein levels and serves as a marker of ferroptosis 8

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JS-K is reportedly activated by glutathione conjugation by glutathione transferase (GST), but the scope of activities among the numerous members of the GSTome is unknown

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