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The peptide was originally developed by researchers seeking to isolate the lipolytic effects of growth hormone from its other physiological actions

While this application requires further clinical investigation, some studies have shown the peptide stimulating cartilage cell proliferation and demonstrating potential benefits for osteoarthritis treatment

In animal models, this is the window over which metabolic and adipocyte changes accumulate

Psychiatry 26 (2), 105109

Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing

Research has documented reduced fat mass, decreased adipocyte size, and shifts in adipose tissue gene expression patterns toward fat-mobilizing rather than fat-storing phenotypes