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GLOBOCAN-2022 recorded 324,398 new cases and 206,839 deaths worldwide, and demographic modelling predicts that annual incidence will exceed half a million by 2050, with the greatest absolute growth in Asia and the steepest percentage rise in sub-Saharan Africa [38]

APP/PS1 transgenic mice show depressive-like behaviors, demonstrated by reduced sucrose preference, increased immobility in the TST and forced swimming test (FST), as well as social withdrawal before A plagues are detected (Romano et al., 2015

2017 Sep;41(4):46675

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