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This cascade leads to endothelial injury, glomerular hyperfiltration, and enhanced macromolecule permeability which causes inflammation and glomerulosclerosis

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FASEB J 19:15046, PMID: 15972297 Kanno T, Nishizaki T (2001) Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c

Xi J, Chen Y, Jing J, Zhang Y, Liang C, Hao Z et al (2019) Sirtuin 3 suppresses the formation of renal calcium oxalate crystals through promoting M2 polarization of macrophages

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Zangs study (Zang et al., 2019) found that eleutheroside B offers protection against Cis-induced AKI in mice, mitigating the damage caused by cisplatin exposure and hypoxia-reoxygenation in HK-2 cells