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It has been shown to target fat metabolism with a precision that full-length hGH cannot match, avoids many of hGH's most significant risks, and carries a well-characterized safety profile from over 900 clinical trial participants

These numbers are unprecedented for a non-surgical, pharmacological intervention and notably the weight-loss curve had not fully plateaued at 48 weeks, suggesting that even greater reductions might occur with longer exposure

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The dose escalation schedule of these medications also plays a role, with gastrointestinal symptoms often more pronounced during dose increases

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