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There's immune dysregulation

The manufacturer stores batches at various temperatures for months and years, measuring degradation at every step

[DOI] [PubMed] [Google Scholar] 95.Baumgartner T., Heinrichs M., Vonlanthen A., Fischbacher U., Fehr E

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The numbers below come from two places: rodent studies scaled to a human size (allometric scaling) and several years of research community use reports

Altogether this provided rationale for investigating the potency of FOXO4-DRI on tubular senescence and renal function in in vivo