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Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy

Cryo-electron microscopy work published in 2025 resolved calcitonin- and amylin-family peptides bound to active-state, Gs-coupled receptor complexes and compared their binding modes [7]

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Additionally, mitochondrial energy metabolism and inflammatory cytokines pathways were unaffected or downregulated, and no changes in functional readouts like hand grip strength were observed

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