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5-Amino-1MQ inhibits the enzyme NNMT (nicotinamide N-methyltransferase), which preserves intracellular NAD+ and activates AMPK-dependent mitochondrial fat oxidation

initial results have been reported at an earlier Pernicious Anaemia Society meeting, and these presentations can be found online on the PAS website and / or YouTube

This does not completely negate the peptide, but it reduces efficiency