Wilson LM, Tharmarajah S, Jia Y, Semba RD, Schaumberg DA, Robinson KA
it signals a chemical change
Pharmacological treatment options for metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus: A systematic review
doi: 10.1038/s41580-022-00506-6 61 DumauthiozNTschumiBWenesMMartiBWangHFrancoFet al
[DOI] [PubMed] [Google Scholar] 150.Conus P., Seidman L.J., Fournier M., Xin L., Cleusix M., Baumann P.S., Ferrari C., Cousins A., Alameda L., Gholam-Rezaee M., Golay P., Jenni R., Woo T.W., Keshavan M.S., Eap C.B., Wojcik J., Cuenod M., Buclin T., Gruetter R., Do K.Q
However, if the intracellular concentration exceeds maximum metabolic capacity (saturates the enzyme) drug levels within the cell remain high, so reducing uptake (reduced concentration gradient) and ER