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In the normal rats, L-NAME reduced bleeding time (and induced thrombocytopenia and thereby, the NOS-blocker-prothrombotic effect), L-arginine prolonged bleeding time (thereby showing the NOS-substrate-antithrombotic effect) [2931]

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The only change made was the adjustment of the recording electrodes which were now placed in the apical dendritic field

For researchers focused specifically on weight management outcomes, the full escalation to 12mg provides the most robust data, though the 8mg dose produced 22.8% weight loss, only 1.4 percentage points less

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