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Curcumin can also markedly upregulate CD3 - CD19 + CD1d + , CD3 - CD19 + CD25 + , CD3 - CD19 + Foxp3 + Breg cells level and significantly down-regulate CD3 - CD19 + PD-L1 + , CD3 - CD19 + tim-1 + , CD3 - CD19 + CD27 + Breg cells level in DSS-induced colitis mice [264]

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