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Calculations from immunolocalization studies performed in parallel with whole tissue quantification yielded estimated glutathione concentrations of 1 to 6 mM in the plastids, cytosol, and mitochondria of Arabidopsis Col-0 leaf mesophyll cells, with concentrations in the vacuole below 50 M (Queval et al., 2011)

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By delivering intact glutathione directly into the mast cells via liposomal membrane fusion, the supplement helps to quench the oxidative "danger signals" that provoke degranulation