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Moreover, recent well-controlled animal studies have demonstrated that hepatic GSH may actually promote lipid accumulation and exacerbate MASLD (1114), though the underlying molecular mechanisms remain largely undefined

Blood glutathione levels return toward baseline within 24 to 72 hours after a single IV push

Lee HB, Ha H, Kim SI, Ziyadeh FN

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Researchers recommend that future studies focus on developing a standardized KD treatment strategy, including precise duration and regimen, to minimize adverse effects [153]