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Thus, specific metal-based nanoparticle-based therapeutics have already been approved by the United States Food and Drug Administration (FDA) ( While the increasing need for novel drugs or drug-release systems has led to vast advancements in nanomedicine, some safety concerns exist (Liu et al., 2020a

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conducted a 12-week facial study of 67 women, reporting that GHK-Cu cream was used twice daily to improve the appearance of aging skin, increase skin thickness, reduce wrinkles, and biopsy histological analysis

and Schmid, R