[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Boucher B.J
doi: 10.1016/j.jconrel.2024.08.036 120 PengP.FengT.YangX.NieC.YuL.DingR.et al
AcAc is converted in a reversible reaction catalyzed by D--hydroxybutyrate dehydrogenase (BDH1), leading to the formation of BHB, or undergoes non-enzymatic decarboxylation with the formation of acetone (Figure 2) (104, 105)
For instance, the combination of inhibitors targeting the PI3K/Akt pathway with paclitaxel drugs has been shown to enhance the sensitivity of paclitaxel (109)
Thus, sensitized mice have competing protective and sensitizing responses to challenge infection, which typically manifest as an extreme bimodal distribution of infection burdens by 24 h post-infection 5
Sohal RS, Farmer KJ, Allen RG, Ragland SS, 1984