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The initial detection of viral dsRNA by MDA5 triggers expression of type I IFN-associated genes via MAVS, preparing the host for an antiviral response and limiting early viral replication (98, 156)

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Interpreting results and measuring success Defining success: Stability (no progression) often represents success for chronic degenerative diseases

Notably, one area that has not been extensively addressed in the studies included in this review but is gaining attention in the broader literature is the integration of neurophysiological markers into VR-based cognitive training