quitting tobacco use is difficult because How to Quit Smoking: A 5-Step Approach Nicotine Withdrawal: Symptoms, Treatment &

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In many cases, surgery has to be performed to correct this problem, Some of the more serious issues associated with smokeless tobacco include: Leukoplakia

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The anti-tumor function of cisplatin, an intercalating agent, has been linked to its ability to crosslink with the purine bases on the DNA, causing DNA damage, interfering with DNA repair mechanisms, and subsequently inducing cell cycle arrest and apoptosis in cancer cells 46