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The injectable GHK-Cu works at a different tissue level than the topical application that follows

Hyperadrenocorticism (Cushings syndrome), the oversecretion of the hormone cortisol by the adrenal gland, can cause water and sodium retention in the kidney (leading to hypertension) and a number of urine abnormalities

My first injection I took only 1.25 units to minimize any possible side effects

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity Nature

After that initial period, it is common to continue injections monthly, though less frequent intervals might be OK if cobalamin blood levels are supportive

Also, in chronically alcohol drinking rats, BPC 157 may prevent and reverse portal hypertension (30)