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Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed

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For instance, Casgevy, based on the CRISPR/Cas9 gene-editing system, was the first successful attempt at disease treatment, promising a one-time treatment for a lifelong effect. However, the complexity of clinical applications and the difficulty of target selection in gene editing have led to long treatment cycles and high costs

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