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In some instances, administration of an otic formulation or composition described herein lowers the ratio of C max to C min and provides a larger Area Under the Curve (AUC) with a prolonged PK profile based on the C min

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[ 4 ] Another area of interest involves DSIP's potential effects on the hypothalamic-pituitary-adrenal (HPA) axis, a key regulator of the physiological stress response

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