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16 (4), 465.e1-465.e8 (2020)

To this end, we evaluated multiple cellular parameters including loss of cell viability, caspase 3 activation, GSH-conjugate formation, GSH homeostasis, and cellular stress response pathway activation in mock- and GSTP1 -transfected HepG2 cells

Philpott JD, Witard OC, Galloway SDR

During 72 weeks of treatment, people taking tirzepatide at doses of 5, 10, or 15 mg lost an average of 15.0%, 19.5%, and 20.9%, respectively, compared with just 3.1% in people taking a placebo