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Animal models of localized IGF-1 overexpression show muscle hypertrophy is satellite cell-dependent (PMID 10632630), and satellite cell activation in humans requires mechanical loading

Additionally, patients who are exposed to environmental oxidative stress or suffer from genetic deficits (such as methylation pathways) would have more favorites results by related nutrient supplementation, compared with other subjects

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The effect of high mobility group box-1 protein on splenic dendritic cell maturation in rats