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doi: 10.1146/annurev.immunol.15.1.203 193 RostamiJFotakiGSiroisJMzezewaRBergstrmJEssandMet al

In both animal models and controlled human studies, DSIP has been associated with modulation of endogenous sleep-regulating systems rather than direct sedative activity, supporting its classification as a neuromodulator rather than a pharmacological hypnotic agent [2]

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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

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Woo, Y.C., Xu, A., Wang, Y