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reported that melatonin treatment reduced brain water content and improved BBB integrity compared with untreated controls (146)

Right now, the evidence doesnt support

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Elsevier (2015)

LCMS analysis was performed using a Vanquish F ultrahigh-performance LC system (Thermo Fisher Scientific) coupled with a Thermo Orbitrap Exploris 480 MS instrument on an Acclaim C30 column (3 m, 2.1 150 mm, 45 C)